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208 Breeds, 422 Health Conditions  |  Find a Vet

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Pulmonary Infiltrates of Eosinophils




Condition Overview

Pulmonary Infiltrates of Eosinophils (PIE) is an uncommon respiratory disease in dogs, caused by the presence of numerous eosinophils (a type of white blood cell) in the blood, respiratory secretions, and lungs.


Signs of PIE are fever, cough rapid breathing, and weight loss, Listening to the chest with a stethoscope reveals dry, crackling sounds. The diagnosis is made by finding eosinophils in the blood and transtracheal washings.


Eosinophils usually indicate a hypersensitivity reaction. Accordingly, an allergic basis for PIE has been proposed. The source of the allergy is ususally unknown.


Before a diagnosis of PIE can be made, other causes of eosinophilia, such as heartworms, lungworms, migrating intestinal parasites, fungal infections, and lymphosarcoma, must be excluded.


Treatment involves large doses of corticosteroids that are tapered off gradually over several weeks. many dogs recover fully, but relapses can occur.


There is no prevention for this condition.


Please contact your veterinarian with questions regarding this condition.

Show Sources & Contributors +


Dog Owners Home Veterinary Handbook

Publisher: Wiley Publishing, 2007

Website: http://www.wiley.com/WileyCDA/

Authors: Debra M. Eldredge, Liisa D. Carlson, Delbert G. Carlson, James M. Giffen MD

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